STING Agonist cGAMP Is a Potent Vaccine Adjuvant
We know the cGAS–STING pathway is a key activator of the innate immune response to cellular damage or microbial infection. Cyclic GMP-AMP...
What Makes Cortisol Different Among Species?
STUMPED? The molecules, of course, are 100% identical. The structure of the cortisol molecule is exactly the same regardless of...
Neonatal Stress Alters Adult Behavior and Stress Reactivity
Early-life stressful experiences can have negative consequences on brain maturation. To understand the long-term implications of neonatal stress, researchers from...
3′,3′-Cyclic GAMP Assay: The Newest Tool in the Researcher’s Arsenal
Cyclic dinucleotides are the most abundant second messengers in bacteria, modulating a variety of cellular activities in prokaryotic cells. 3’3’-cyclic GAMP...
Nuclear Tethering of cGAS Prevents STING Autoreactivity
The presence of DNA in the cytoplasm of eukaryotic cells is an alarm signal indicating cellular damage or microbial infection. The...
Post-Stroke Dementia Biomarkers
Stroke is the fifth leading cause of death in the United States and is a major cause of serious disability...
Dinural Glucocorticoid Hormone Response
“Glucocorticoid hormones are secreted with a prominent daily rhythm, but their diurnal genomic actions remain uncharacterized. Quagliarini et al. show...
Developing Tools For Conservation Biology
Today, almost 17,000 species are threatened with extinction. This number encompasses only those species that are assessed and well studied....
Anxiety and Sex Hormones
Statistics from the National Institute of Mental Health show almost 20% of all adults in the United States suffer from...
10 Amazing Neurosteroid Facts
Allopregnanolone (5α-pregnan-3α-ol-20-one, Allo) Allopregnanolone is released by the adrenal gland in response to stress providing delayed negative feedback inhibition of the...
What More Could You Ask For?
Nitric oxide (NO) is a diffusible, transient, reactive molecule, and an important regulator of cardiovascular, neurological, and immunological systems. NO is generated...
Parturition Prediction Made Easy
Reliable pregnancy diagnosis in captive breeding programs can be challenging. Accurate, non-invasive biomarkers are vital for successful reproductive management...